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07.02.2011
17.15 Uhr
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When two is not enough: using triplets of spikes to model synaptic plasticity
BCCN/BFNT AG-Seminar
Dr. Julijana Gjorgjieva
Center for Brain Science, Harvard University, Cambridge, MA, USA
Ludwig-Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
Abstract
Abstract
Synaptic plasticity depends on the precise timing of presynaptic and postsynaptic spikes and is
believed to provide the basis for learning and memory. Traditionally, pairs of spikes have been assumed
to be the building blocks governing synaptic change. If a presynaptic spike precedes a postsynaptic
spike, synapses undergo long-term potentiation, whereas if the order is reversed, synaptic strength
is depressed (known as spike timing-dependent plasticity, or STDP). Recent work has suggested that
it is more appropriate to describe synaptic plasticity as a function of triplets of spikes (1 pre
and 2 post). I will describe a triplet STDP model which can capture a variety of experimental data,
and present a novel theoretical analysis of the model which has previously only been studied numerically.
Under certain conditions, a direct correspondence can be made between the triplet STDP rule and the
rate-based Bienenstock-Cooper-Munro (BCM) plasticity rule. The latter model has been shown to maximize
the selectivity of the postsynaptic neuron, and thereby offers a possible explanation for
experience-dependent cortical plasticity such as orientation selectivity. The analysis of the
triplet STDP rule can be extended to spatio-temporal correlations of higher-than-second order,
thus generalizing selectivity to patterns with higher-order correlations which exist in natural
stimuli and have been measured in the brain. Finally, I show that this sensitivity of the triplet
STDP rule to higher-order correlations can be used to develop direction and speed selectivity.
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08.02.2012
17.00 Uhr
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18. Göttinger MS-Lecture
Prof. Dr. med. Thomas Henze
Reha-Zentrum Nittenau, Rehabilitationsklinik für Neurologie-Geriatrie-Urologie
Hörsaal 55 Universitätsklinikum Göttingen
no abstract
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14.02.2012
17.15 Uhr
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Social networks and cooperative behavior
Arbeitsgruppen-Seminar
Prof. Dr. Dirk Semmann
Courant Research Centre "Evolution of Social Behaviour", Universität Göttingen
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
no abstract
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28.02.2012
17.15 Uhr
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Binaural hearing: Lessons from evolution
BFNT/BCCN AG-Seminar
Prof. Dr. Catherine Carr
Department of Biology, University of Maryland, USA
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
Abstract
Abstract
Ears capable of detecting airborne sound have arisen repeatedly and independently in the five major tetrapod groups - the anurans, turtles, lizards and snakes, archosaurs (birds and crocodiles) and mammals. All use a major cue for localization, the arrival time information from each ear. In birds, arrival time difference processing is mediated by neural circuits which form maps of sound location in the CNS. In the mammals, however, confirmation of a map is lacking. Instead, recent work in small mammals suggests that sound source location might be encoded by activity in two broad, hemispheric spatial channels. I will discuss the evolution of neural codes for computing sound location in birds, alligators, lizards and mammals.
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9.|10.03.2012
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Eröffnungssymposium
Verschiedene Referenten
Hörsaal 525, Universitätsmedizin Göttingen, Robert-Koch-Str. 40
no abstract
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11.04.2012
9.00 - 16.00 Uhr
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CRG 241 Kick-off Symposium
Prof. Dr. Ezra Susser
Dept. of Psychiatry, Columbia University, New York, USA
Prof. Dr. Francis McMahon
Genetic Basis of Mood and Anxiety Disorders, NIMH, Bethesda, USA
Prof. Dr. Christian Büchel
Inst. for Systemic Neurosciences, University of Hamburg
Prof. Dr. Julio Licinio
Translational Medicine, ANU College of Medicine, Biology & Environment, Canberra, Australia
Prof. Dr. Schahram Akbarian
Brudnick Neuropsychiatric Research Institute, University of Massachusetts, USA
Prof. Dr. Suzanne Leal
Dept. of Molecular & Human Genetics, Baylor College of Medicine, Houston, USA
Prof. Dr. Boris Quednow
Experimental and Clinical Pharmacopsychology, University of Zurich, Switzerland
Lecture Hall AUDI 11, Auditorium, Weender Landstr. 2
no abstract
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16.04.2012
15.15 Uhr
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n.A.
MPI Kolloquium
Dr. Andrei Lupas
Max-Planck-Institut für Entwicklungsbiologie, Tübingen
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
no abstract
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17.04.2012
17.15 Uhr
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Activity-dependent plasticity at the axon initial segment
BCCN/BFNT AG-Seminar
Dr. Matthew Grubb
MRC Centre for Developmental Neurobiology, King's College London, UK
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
no abstract
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25.04.2012
15.15 Uhr
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Unwiring the brain, towards a complete circuit diagram of the central nervous system
MPI Kolloquium
Prof. Dr. Winfried Denk
Max-Planck-Institut für Neurobiologie, Martinsried
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
no abstract
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22.05.2012
17.15 Uhr
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n.A.
BCCN/BFNT AG-Seminar
Prof. Dr Ed Boyden
Synthetic Neurobiology Group, MIT Media Lab, Cambridge, USA
Ludwig Prandtl Hörsaal, Am Faßberg 11, AI-Gebäude
no abstract
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